Atm protein

Premium sportvoeding voor de beste prijs. Voor 18 uur besteld, de volgende dag in huis. Body & Fit: Daar waar premium kwaliteit, innovatie en betaalbaarheid samenkomen. Shop nu Check nu onze hoogstaande kwaliteit producten met de scherpste prijzen in Europa. Europa's nr. 1 sportvoedingsmerk. Beste kwaliteit & lage prijze Die Serin-Proteinkinase ATM ist ein Enzym im Zellkern von Tier- und Pilzzellen. Es fungiert als Sensor von DNA -Schäden, vor allem von Doppelstrangbrüchen. Bei Schäden durch UV-Strahlung kann ATM indirekt über ATR (Ataxia telangiectasia and Rad3-related protein) aktiviert werden

Die Serin-Proteinkinase ATM, ATM für Ataxia Telangiectasia Mutated, ist ein Enzym, das als Signal-Transducer für DNA-Schäden dient, insbesondere für Doppelstrangbrüche ATM serine/threonine kinase, symbol ATM, is a serine / threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis ATM protein is best known for its role in the DNA damage response. However, it is increasingly clear that defects in the DNA damage response alone cannot explain the range of neurologic and neuropathologic changes that are observed in patients with ataxia telangiectasia. Neuropathologic and imaging studies suggest that Purkinje cells are particular targets of ataxia telangiectasia but the. ATM (ATM Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with ATM include Ataxia-Telangiectasia and Mantle Cell Lymphoma. Among its related pathways are ATM Pathway and Transcriptional misregulation in cancer Deeper understanding of the spatial organization of these protein assemblies (Chapman et al., 2012) and the temporal hierarchy of events within them may elucidate ATM's role not only as an enzyme but also as a protein moiety in these structures. Of note, ATM is a large protein of 3,056 residues, of which ∼10% constitute its active site. The regulatory functions of the remaining 90% of this.

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response. The enterovirus 2B protein is a small hydrophobic protein that, upon individual expression, is localized to the endoplasmic reticulum (ER) and the Golgi complex, reduces ER and Golgi complex Ca2+ levels, most likely by forming transmembrane pores, and inhibits protein trafficking through the Golgi complex. At present, little is known about the function of the other picornavirus 2B proteins. Serin-Proteinkinase ATM, das beim Louis-Bar-Syndrom mutierte Protein; atm steht für: Physikalische Atmosphäre, veraltete Einheit für den physikalischen Druck, auch bei Angaben der Wasserdichtigkeit von Uhren; Dies ist eine Begriffsklärungsseite zur Unterscheidung mehrerer mit demselben Wort bezeichneter Begriffe. Zuletzt bearbeitet am 2. Mai 2019 um 22:32. Der Inhalt ist verfügbar unter. BRIP1 kodiert für ein Protein aus der RecQ DEAH Helicase Familie und interagiert mit den BRCT repeats des BRCA1-Proteins. Der Komplex aus BRIP1, BRCA1 und anderer Proteine ist für die Reparatur von DNA-Doppelstrangbrüchen essentiell. Mutationen im Gen BRIP1 sind - zu einem weit geringen Prozentsatz - ebenfalls mit familiärem Brustkrebs assoziiert (Cantor et al.; Cell. 2001;105(1)). BRIP1.

The protein encoded by the ATM gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1 ATM Protein expression data from MOPED 1, PaxDb 2 and MaxQB 3: About this image SOURCE GeneReport for Unigene cluster: Hs.367437. UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315 Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes Pathway & Disease-focused RT 2 Profiler PCR Arrays. The ATM protein coordinates DNA repair by activating enzymes that fix the broken strands. Efficient repair of damaged DNA strands helps maintain the stability of the cell's genetic information. Because of its central role in cell division and DNA repair, the ATM protein is of great interest in cancer research. Other Names for This Gen

human protein atlas information i The Tissue Atlas contains information regarding the expression profiles of human genes both on the mRNA and protein level. The protein expression data from 44 normal human tissue types is derived from antibody-based protein profiling using immunohistochemistry ATM protein plays a critical role in the signal transduction of cell cycle checkpoint, the repair of damaged DNA and the apoptosis. ATM-deficient cells repair the majority of DSBs with normal kinetics but fail to repair a subset of breaks. demonstrated that MRN (Mre11, Rad50, and Nbs1 proteins) stimulates the kinase activity of ATM in vitro toward its substrates p53, Chk2, and histone H2AX. BRCA1 associated ATM activator 1: ABCB7: ATP binding cassette subfamily B member 7: IFIH1: Interferon induced with helicase C domain 1: CCNE1: Cyclin E1: CHEK1: Checkpoint kinase 1: EEF1E1: Eukaryotic translation elongation factor 1 epsilon 1: HUS1: HUS1 checkpoint clamp component : MDC1: Mediator of DNA damage checkpoint 1: RNF103: Ring finger protein 103: SLC19A3: Solute carrier family 19.

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA damage response, and it coordinates checkpoint activation, DNA repair, and metabolic changes in eukaryotic cells in response to DNA double-strand breaks and oxidative stress. Loss of ATM activity in humans results in the pleiotropic neurodegeneration disorder ataxia-telangiectasia. ATM exists in an inactive. 22589 Ensembl ENSG00000085224 ENSMUSG00000031229 UniProt P46100 Q61687 RefSeq (mRNA) NM_000489 NM_138270 NM_138271 NM_009530 RefSeq (protein) NP_000480 NP_612114 NP_033556 Location (UCSC) Chr X: 77.5 - 77.79 Mb Chr X: 105.8 - 105.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X. ATR Andere Namen ATR Serine/Threonine Kinase; FRP1; Ataxia Telangiectasia And Rad3-Related Protein; EC; FCTCS; SCKL1; MEC1; MEC1, Mitosis Entry Checkpoint 1, Homolog; Ataxia Telangiectasia And Rad3 Related; Serine/Threonine-Protein Kinase ATR; Mitosis Entry Checkpoint 1; Homolog (S. Cerevisiae); FRAP-Related Protein-1; FRAP-Related Protein 1; SCK

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  1. ATM gene: MedlinePlus Genetic
  2. Tissue expression of ATM - Summary - The Human Protein Atla
  3. 472 - Gene ResultATM ATM serine/threonine kinase [ (human)
  4. Search: ATM - The Human Protein Atla
  5. Mechanisms of ATM Activation Annual Review of Biochemistr
  6. ATRX - Wikipedi
  7. Atm - Serine-protein kinase ATM - Mus musculus (Mouse

ATR-Protein - Wikipedi

  1. MRN-Komplex - DocCheck Flexiko
  2. The ATM gene and protein - A-T Societ
  3. Human Synthetic Ataxia Telangiectasia Mutated (ATM) Peptid

ATM Antibody (MA1-23152

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DNA damage checkpoint and p53

  1. Ataxia-Telangiectasia Syndrome - Usmle case based discussion
  3. Ataxia telangiectasia

Control of cell cycle - cyclin , CDK, APC , SCF, P53, ATM, ATR

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